Direct flights from Knoxville to Chicago
61 nonstop flights a week on 2 airlines. Zero layovers — one hop from TYS to ORD.
Flight time: about 1h20m nonstop
Which days does it fly?
When does it fly?
Departure times in Knoxville local time, from flights observed over the last 7 days.
| Flight | Departs | Duration | Days |
|---|---|---|---|
| United UAL2801 | 6:03a | 1h21m | Fri |
| United UAL2801 | 6:10a | 1h20m | Mon, Tue, Wed, Sat |
| United UAL2801 | 6:17a | 1h23m | Sun |
| United UAL2801 | 7:19a | 1h20m | Thu |
| American ENY3716 | 8:03a | 1h11m | Fri |
| American ENY3716 | 8:08a | 1h13m | Mon, Wed, Thu, Sun |
| American ENY3716 | 8:30a | 1h22m | Sat |
| American ENY9874 | 10:51a | 1h22m | Tue |
| GoJet GJS4543 | 10:51a | 1h20m | Thu, Sat, Sun |
| GoJet GJS4543 | 10:56a | 1h20m | Mon–Tue |
| GoJet GJS4543 | 11:15a | 1h16m | Wed |
| American ENY4102 | 11:32a | 1h12m | Wed, Sat |
| American ENY4102 | 11:39a | 1h34m | Thu–Fri |
| American ENY4102 | 11:50a | 1h20m | Mon, Sun |
| SkyWest SKW6445 | 11:59a | 1h17m | Tue |
| GoJet GJS4543 | 12:05p | 1h20m | Fri |
| American ENY3837 | 1:07p | 1h27m | Tue |
| American ENY3571 | 1:28p | 1h13m | Tue |
| American ENY4002 | 1:31p | 1h8m | Sat |
| American ENY4002 | 1:39p | 1h15m | Fri |
| GoJet GJS4404 | 2:02p | 1h20m | Wed–Sat |
| GoJet GJS4404 | 2:06p | 1h24m | Tue |
| American ENY4002 | 2:13p | 1h13m | Sun |
| GoJet GJS4404 | 2:20p | 1h24m | Mon, Sun |
| American ENY4002 | 2:32p | 1h19m | Mon |
| American ENY4105 | 4:54p | 1h33m | Mon, Fri |
| American ENY4105 | 5:03p | 1h14m | Wed, Thu, Sat, Sun |
| United UAL1081 | 6:12p | 1h21m | Tue, Thu, Sat |
| United UAL1081 | 6:19p | 1h20m | Wed, Fri, Sun |
| United UAL1081 | 6:27p | 1h16m | Mon |
| SkyWest SKW4970 | 7:20p | 1h15m | Tue |
| SkyWest SKW6344 | 8:22p | 1h25m | Thu–Sat |
| SkyWest SKW6344 | 8:33p | 1h25m | Sun |
| SkyWest SKW6344 | 8:43p | 1h27m | Wed |
| SkyWest SKW6344 | 8:48p | 1h18m | Mon |
American
UnitedThe route
One hop: TYS → ORDDrag to pan · scroll with ⌘/Ctrl to zoom · arrow keys when focused
Nonstop from Knoxville (TYS) to Chicago (ORD)
McGhee Tyson Airport (TYS) has 61 nonstop flights a week to Chicago (ORD), operated by American and United. No layovers, no connections — one hop out of TYS and you're there.
This route flies every day of the week, so any travel day works. Route data updated September 2026 from observed departures.
Route data updated September 2026 from observed flight departures. Schedules change — always confirm with the airline before booking.
How long is the flight from Knoxville to Chicago?
The nonstop flight from Knoxville (TYS) to Chicago (ORD) takes about 1h20m in the air, based on recently observed nonstop departures.
How long does it take to drive from Knoxville to Chicago?
Driving from Knoxville to Chicago takes about 8h 9m, covering roughly 541 miles. The nonstop flight takes about 1h20m.