Direct flights from Knoxville to Key West
2 nonstop flights a week on 1 airline. Zero layovers — one hop from TYS to EYW.
Flight time: about 2h29m nonstop
Flying back? Key West → Knoxville · 2 nonstop flights a week
Which days does it fly?
When does it fly?
Departure times in Knoxville local time, from flights observed over the last 7 days.
| Flight | Departs | Duration | Days |
|---|---|---|---|
| Allegiant AAY1401 | 6:20a | 2h27m | Fri |
| Allegiant AAY3064 | 8:00a | 2h30m | Mon |
AllegiantOther airports near Knoxville with nonstops to Key West
| Airport | Distance | Flights / wk |
|---|---|---|
| AVL — AshevilleAllegiant | 86 mi | 2 |
The route
One hop: TYS → EYWDrag to pan · scroll with ⌘/Ctrl to zoom · arrow keys when focused
Nonstop from Knoxville (TYS) to Key West (EYW)
McGhee Tyson Airport (TYS) has 2 nonstop flights a week to Key West (EYW), operated by Allegiant. No layovers, no connections — one hop out of TYS and you're there.
This route flies on Monday and Friday — check the schedule grid above before you pick a travel day. Route data updated October 2026 from observed departures.
Route data updated October 2026 from observed flight departures. Schedules change — always confirm with the airline before booking.
How long is the flight from Knoxville to Key West?
The nonstop flight from Knoxville (TYS) to Key West (EYW) takes about 2h29m in the air, based on recently observed nonstop departures.
How long does it take to drive from Knoxville to Key West?
Driving from Knoxville to Key West takes about 15h 45m behind the wheel — roughly 1,034 miles, or about 2 days of real driving. The nonstop flight takes about 2h29m.
Is there a nonstop return flight from Key West to Knoxville?
Yes — 2 nonstop flights a week from Key West (EYW) back to Knoxville (TYS) on Allegiant, based on recently observed departures.